Tina Bott

Current Research Interests: 1) Extraction and Synthesis of Bioactive Natural Products from Invasive Plant Species Found in Alberta. Pyrrolizidine alkaloids (PAs) are a diverse class of natural products found in plant, bacterial and fungal sources. They exhibit a wide range of biological activities, both toxic and beneficial, and are a major area of interest in chemistry, biochemistry and the agricultural sciences. With my background in both synthetic chemistry and natural product extraction and characterization, this presents a unique opportunity to find new PAs in local environments, determine their biological activity, and develop a simple route to access larger quantities of molecules for screening. 2) Development of New Chemical Transformations The development of new ways to form carbon-carbon bonds is an ongoing mission for organic chemists everywhere. The constant study of new reactions expands the synthetic chemistry toolbox, allowing easier access to more complex targets, such as natural products. Research in the Bott lab will consider new ways to generate carbon-carbon and carbon-nitrogen bonds via carbenes derived from acyl silanes or diazocarbonyl compounds. Application of these newly developed transformation towards the synthesis of small, carbocyclic or heterocyclic molecules will also be explored. | Organic chemistry, synthetic methodology, carbenes, acyl silanes, natural products, alkaloids, medicinal chemistry

Tina Bott is Assistant Professor | Discipline Advisor, Chemistry at MacEwan University. Their stated interests include Current Research Interests: 1) Extraction and Synthesis of Bioactive Natural Products from Invasive Plant Species Found in Alberta. Pyrrolizidine alkaloids (PAs) are a diverse class of natural products found in plant, bacterial and fungal sources. They exhibit a wide range of biological activities, both toxic and beneficial, and are a major area of interest in chemistry, biochemistry and the agricultural sciences. With my background in both synthetic chemistry and natural product extraction and characterization, this presents a unique opportunity to find new PAs in local environments, determine their biological activity, and develop a simple route to access larger quantities of molecules for. This summary considered all 2 collected sources.